“What is the connection between leptin and metabolic syndrome?” you may ask, but actually they are connected in many different ways. You see, leptin is a protein hormone which plays a key role in regulating energy intake and energy expenditure. This includes appetite and metabolism.
Just as people with metabolic disorders may be resistant to the insulin hormone, it seems as though obese may become resistant to leptin as well. In other words, Leptin is the hormone that reduces appetite in our bodies, however, high levels are found in obese people because they have become resistant to its effects. It may also be that some obese people may be flawed in some way that the signal is not receive the feeling of being ‘full’ at all (or as much).
In any case, this ‘leptin resistance’ is at the very least a contributor to the eventual formation of metabolic syndrome …